In the last decade, an extensive effort has been made to characterize the human microbiota, due to its clinical and economic interests. However, a metagenomic approach to the skin microbiota is hampered by the high proportion of host DNA that is recovered. In contrast with the burgeoning field of gut metagenomics, skin metagenomics has been hindered by the absence of an efficient method to avoid sequencing the host DNA. We present here a method for recovering microbial DNA from skin samples, based on a combination of molecular techniques.
To access to full article: A new method for extracting skin microbes allows metagenomic analysis of whole-deep skin (Image from the article)
The resident microbial community, harboured by humans in sites such as the skin and gastrointestinal tract, is enormous, representing a candidate environmental factor affecting susceptibility to complex diseases, where both genetic and environmental risk factors are important. The potential of microorganisms to influence the human immune system is considerable, given their ubiquity. The impact of the host-gene-microbe interaction on the maintenance of health and the development of disease has not yet been assessed robustly in chronic inflammatory conditions.
To access to abstract: The bacterial skin micro biome in psoriatic arthritis an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances (Image from http://arthritishelppc.blogspot.com/2012/04/psoriatic-arthritis-vs-psoriasis.html)
Artist Sonja Bäumel has explored the human skin microbiome in her project ‘Cartography of the Human Body’. To illustrate the diversity of the bacteria and fungi on the skin, she cultured isolates from her own body to create an innovative art project.
To access to full article: Illustrating the human body with ‘MIcrocartography’ (Image by Sonja Bäumel, A Petri dish map of artist Sonja Bäumel’s body shape)
Dr. Julie Segre discusses on Human Skin Microflora: DNA Sequence-Based Approach to Examining Hand Disease (Image from http://www.jonbarron.org/natural-health/skin-anatomy-healthy)
Dr. David Relman from Standford University discusses on diversity, stability and resiliance of the microbiome. (Image from the lecture)
The skin is colonized by a plethora of microbes that include commensals and potential pathogens, but it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity, and quantity of the skin microbiota. Here we reveal an interactive role for complement incutaneous host-microbiome interactions.
To access to abstract: Complement modulates the cutaneous microbiome and inflammatory milieu (Image adapted from http://www.pickyourdrugs.com/all-news/hand-bacteria-may-one-day-aid-forensic-identification-study)
Circumcision is associated with significant reductions in HIV, HSV-2 and HPV infections among men and significant reductions in bacterial vaginosis among their female partners.
To access to full article: The Effects of Circumcision on the Penis Microbiome (Image adapted from http://guardianlv.com/2013/09/does-circumcision-prevent-hiv/)